SonoWell All-in-One ultrasound system-Worldwide Technology (S.H)

SonoWell All-in-One ultrasound system

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SonoWell All-in-One ultrasound system
description：	SonoWell® (patented solution, CE marked) is the first “all in one” ultrasound system aimed to Research Cell Applications, where Ultrasound Acoustic Energy is deposited on cell substrates in in-vitro and ex-vivo tissue experiments. It is the first commerci

Summarize:
SonoWell® (patented solution, CE marked) is the first “all in one” ultrasound system aimed to Research Cell Applications, where Ultrasound Acoustic Energy is deposited on cell substrates in in-vitro and ex-vivo tissue experiments. It is the first commercially available all-in-one ultrasound system specifically designed for experimental applications on cells and tissue samples.Designed for biologists in biomedical research, SonoWell® is a configurable, modular, and expandable integrated device that enables ultrasound experiments using standard well plates from 6 to 96 wells. With a single set-up, it manages programming, temperature control, sample movement, ultrasound delivery, and data analysis. This integrated approach ensures flexible experimental design and produces accurate, homogeneous, reproducible, and comparable results.
Inside a compact 40 × 40 × 40 cm rack, easily placed on a laboratory benchtop, shelf, or cart, SonoWell® houses the ultrasonic frequency generator, amplifier, and fluidic control unit. Separate warm and cold circuits manage sample thermostating and transducer cooling, with pumps and 10 µm filters for particle removal and degassing. Quick-release connectors simplify filter replacement, while the entire process is programmed and controlled through the SonoWell Soft© software. The plates containing the biological samples are immersed in the thermostating tank and moved by high-precision stepper motor systems (2.5µm step), controlled by the System and programmed via SonoWell Soft©. The thermostating tank, the transducer holder, and the precision plate movement mechanics are structurally integral, therefore sharing the reference system of the coordinates and guaranteeing the perfect orthogonality of the axes and planes of the transducers.

Advantage
Configurable from 1 to 4 transducers, also at different frequencies, which can simultaneously sonicate on different wells, using common commercial plates up to 96 wells, with a frequency range from 500 kHz to 5 MHz, and making it possible to compare the frequency effect in experiments conducted on the same plate. Inno-Sol’s Patented Technology allows different frequency transducers to share the same Near/Far Field plane.
The entire experimental workflow is managed by the proprietary software SonoWell Soft©. Featuring a user-friendly, multi-window graphical interface, it allows researchers to program all experimental parameters and protocols, even offline. Users can configure one to four transducers operating independently, select the plate type, define ultrasound emission parameters such as frequency, intensity, sonication time, duty cycle, and repetition frequency for each well, and set synchronized plate movement paths. Offline programmability on different Windows PCs allows multiple researchers or teams to share the instrument efficiently, using machine time only for experiment execution and significantly improving laboratory productivity and flexibility.

Key Feature
Block-US (patented solution) is the solution to the problem of side-leakage and modes conversion of propagating waves when the commercially available well-plates is stimulated from ultrasound waves.

SonoWell® (patented solution, CE marked) is the first “all in one” ultrasound system aimed to Research Cell Applications, where Ultrasound Acoustic Energy is deposited on cell substrates in in-vitro and ex-vivo tissue experiments

Inno-Cap patented solution) is a lid with pegs protruding toward medium solution within the well, allowing continuity of acoustic impedance to the ultrasound waves with aqueous medium solution.

Application:
Ultrasound as a New Method for the Release and Identification of Novel microRNAs and Proteins as Candidate Biomarkers in Pancreatic Cancer
FUS and surfactant-based nanocarriers: A combined strategy for nose to brain drug delivery
Exploiting Focused Ultrasound to Aid Intranasal Drug Delivery for Brain Therapy
Ultrasound-Based Method for the Identification of Novel MicroRNA Biomarkers in Prostate Cancer
Low-intensity pulsed ultrasound affects growth, differentiation, migration, and epithelial-to-mesenchymal transition of colorectal cancer cells
Ultrasound affects minimal inhibitory concentration of ampicillin against methicillin resistant Staphylococcus aureus USA300
Specification:
Cell function data: Changes in cell viability, proliferation ability, migration and invasion ability.
Molecular biology data: By analyzing the supernatant of treated cell cultures, bio-molecules such as microRNAs (miRNAs) and proteins that have been "released" can be detected. Research has successfully utilized this to identify potential biomarkers related to pancreatic cancer and prostate cancer.
Physical parameter data: The system records and outputs specific parameters of the ultrasound treatment, such as frequency, sound pressure, intensity (Ispta), duty cycle, etc., to ensure the reproducibility of the experiment.

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